Ontology highlight
ABSTRACT:
SUBMITTER: Blanco D
PROVIDER: S-EPMC4356839 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Blanco Delia D Perez-Herran Esther E Cacho Mónica M Ballell Lluís L Castro Julia J González Del Río Rubén R Lavandera José Luis JL Remuiñán Modesto J MJ Richards Cindy C Rullas Joaquin J Vázquez-Muñiz María Jesús MJ Woldu Ermias E Zapatero-González María Cleofé MC Angulo-Barturen Iñigo I Mendoza Alfonso A Barros David D
Antimicrobial agents and chemotherapy 20150112 4
One way to speed up the TB drug discovery process is to search for antitubercular activity among compound series that already possess some of the key properties needed in anti-infective drug discovery, such as whole-cell activity and oral absorption. Here, we present MGIs, a new series of Mycobacterium tuberculosis gyrase inhibitors, which stem from the long-term efforts GSK has dedicated to the discovery and development of novel bacterial topoisomerase inhibitors (NBTIs). The compounds identifi ...[more]