Ontology highlight
ABSTRACT:
SUBMITTER: Sutherland HS
PROVIDER: S-EPMC8811485 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Sutherland Hamish S HS Lu Guo-Liang GL Tong Amy S T AST Conole Daniel D Franzblau Scott G SG Upton Anna M AM Lotlikar Manisha U MU Cooper Christopher B CB Palmer Brian D BD Choi Peter J PJ Denny William A WA
European journal of medicinal chemistry 20211221
Drug resistant tuberculsosis (TB) is global health crisis that demands novel treatment strategies. Bacterial ATP synthase inhibitors such as bedaquiline and next-generation analogues (such as TBAJ-876) have shown promising efficacy in patient populations and preclinical studies, respectively, suggesting that selective targeting of this enzyme presents a validated therapeutic strategy for the treatment of TB. In this work, we report tetrahydronaphthalene amides (THNAs) as a new class of ATP synth ...[more]