Amphiphilic p-sulfonatocalix[4]arene as "drug chaperone" for escorting anticancer drugs.

ABSTRACT: Supramolecularly constructing multifunctional platform for drug delivery is a challenging task. In this work, we propose a novel supramolecular strategy "drug chaperone", in which macrocyclic amphiphiles directly coassemble with cationic drugs into a multifunctional platform and its surface is further decorated with targeting ligands through host-guest recognition. The coassembling and hierarchical decoration processes were monitored by optical transmittance measurements, and the size and morphology of amphiphilic coassemblies were identified by dynamic light scattering and high-resolution transmission electron microscopy. In cell experiments to validate the drug chaperone strategy, the anticancer activities of free drugs were pronouncedly improved by coassembling with amphiphilic chaperon

SUBMITTER: Wang YX 

PROVIDER: S-EPMC4356970 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature