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New anti-angiogenic leading structure discovered in the fruit of Cimicifuga yunnanensis.

ABSTRACT: Cimyunnins A-C (1-3), characterized with an unusual fused cyclopentenone ring G, together with cimyunnin D (4), possessing a highly rearranged ?-lactone ring F, were characterized from the fruit of Cimicifuga yunnanensis. Their structures were elucidated by spectroscopic analysis, X-ray diffraction, and density functional theory calculations. In addition, cimyunnin A exhibited comparable anti-angiogenic activities to those of sunitinib, a clinically-used first-line angiogenesis inhibitor, in the in vitro and ex vivo studies.

SUBMITTER: Nian Y

PROVIDER: S-EPMC4356973 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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New anti-angiogenic leading structure discovered in the fruit of Cimicifuga yunnanensis.

Nian Yin Y Yang Jing J Liu Tong-Yang TY Luo Ying Y Zhang Ji-Hong JH Qiu Ming-Hua MH

Scientific reports 20150312

Cimyunnins A-C (1-3), characterized with an unusual fused cyclopentenone ring G, together with cimyunnin D (4), possessing a highly rearranged γ-lactone ring F, were characterized from the fruit of Cimicifuga yunnanensis. Their structures were elucidated by spectroscopic analysis, X-ray diffraction, and density functional theory calculations. In addition, cimyunnin A exhibited comparable anti-angiogenic activities to those of sunitinib, a clinically-used first-line angiogenesis inhibitor, in the ...[more]

PMID: 25762443

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