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New Sesquiterpenenoids from Ainsliaea yunnanensis.

ABSTRACT: Investigation of the ethanol extract of the whole plant of Ainsliaea yunnanensis led to the isolation of four new dimeric sesquiterpene lactones, ainsliadimer F-I (1-4), together with seven known dimeric sesquiterpene lactones (5-11) and ten sesquiterpenes (12-21). Their structures were elucidated by spectroscopic methods. The relative stereochemistry of ainsliadimer F was further confirmed by single crystal X-ray diffraction analysis. Compounds 1-21 were tested for the inhibition of nuclear factor kappa B (NF-?B) in the 293-NF-?B-luciferase reporter cell line induced by lipopolysaccharide (LPS), and Compounds 5, 18, 20 and 21 were further tested for the production of TNF-?, IL-1?, IL-6 and IL-10 in RAW 264.7 macrophages induced by LPS. Compounds 5, 18, 20 and 21 exhibited significant activity in anti-inflammatory activity assays.

SUBMITTER: Wu XL

PROVIDER: S-EPMC6273759 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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New Sesquiterpenenoids from Ainsliaea yunnanensis.

Wu Xiang-Lei XL Xiong Xiao-Juan XJ Lu Wen-Quan WQ Huang Hao H Shen Yun-Heng YH Wu Zhi-Jun ZJ Chen Wan-Sheng WS

Molecules (Basel, Switzerland) 20160808 8

Investigation of the ethanol extract of the whole plant of Ainsliaea yunnanensis led to the isolation of four new dimeric sesquiterpene lactones, ainsliadimer F-I (1-4), together with seven known dimeric sesquiterpene lactones (5-11) and ten sesquiterpenes (12-21). Their structures were elucidated by spectroscopic methods. The relative stereochemistry of ainsliadimer F was further confirmed by single crystal X-ray diffraction analysis. Compounds 1-21 were tested for the inhibition of nuclear fac ...[more]

PMID: 27509491

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