Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula.
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ABSTRACT:
SUBMITTER: Meye FJ
PROVIDER: S-EPMC4357267 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Publications
Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula.
Meye Frank J FJ Valentinova Kristina K Lecca Salvatore S Marion-Poll Lucile L Maroteaux Matthieu J MJ Musardo Stefano S Moutkine Imane I Gardoni Fabrizio F Huganir Richard L RL Georges François F Mameli Manuel M
Nature neuroscience 20150202 3
Addictive substances mediate positive and negative states promoting persistent drug use. However, substrates for aversive effects of drugs remain elusive. We found that, in mouse lateral habenula (LHb) neurons targeting the rostromedial tegmental nucleus, cocaine enhanced glutamatergic transmission, reduced K(+) currents and increased excitability. GluA1 trafficking in LHb was instrumental for these cocaine-evoked modifications and drug-driven aversive behaviors. Altogether, our results suggest ...[more]
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