Ontology highlight
ABSTRACT:
SUBMITTER: Jacobs TM
PROVIDER: S-EPMC4357694 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Jacobs Timothy M TM Yumerefendi Hayretin H Kuhlman Brian B Leaver-Fay Andrew A
Nucleic acids research 20141224 5
Degenerate codon (DC) libraries efficiently address the experimental library-size limitations of directed evolution by focusing diversity toward the positions and toward the amino acids (AAs) that are most likely to generate hits; however, manually constructing DC libraries is challenging, error prone and time consuming. This paper provides a dynamic programming solution to the task of finding the best DCs while keeping the size of the library beneath some given limit, improving on the existing ...[more]