Ontology highlight
ABSTRACT:
SUBMITTER: Schwentner R
PROVIDER: S-EPMC4357724 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Schwentner Raphaela R Papamarkou Theodore T Kauer Maximilian O MO Stathopoulos Vassilios V Yang Fan F Bilke Sven S Meltzer Paul S PS Girolami Mark M Kovar Heinrich H
Nucleic acids research 20150220 5
Cell cycle progression is orchestrated by E2F factors. We previously reported that in ETS-driven cancers of the bone and prostate, activating E2F3 cooperates with ETS on target promoters. The mechanism of target co-regulation remained unknown. Using RNAi and time-resolved chromatin-immunoprecipitation in Ewing sarcoma we report replacement of E2F3/pRB by constitutively expressed repressive E2F4/p130 complexes on target genes upon EWS-FLI1 modulation. Using mathematical modeling we interrogated f ...[more]