Ontology highlight
ABSTRACT:
SUBMITTER: Giorgi C
PROVIDER: S-EPMC4745699 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Giorgi Chiara C Boro Aleksandar A Rechfeld Florian F Lopez-Garcia Laura A LA Gierisch Maria E ME Schäfer Beat W BW Niggli Felix K FK
Oncotarget 20151001 30
Ewing sarcoma (ES) is the second most frequent bone cancer in childhood and is characterized by the presence of the balanced translocation t(11;22)(q24;q12) in more than 85% of cases, generating a dysregulated transcription factor EWS/FLI1. This fusion protein is an essential oncogenic component of ES development which is necessary for tumor cell maintenance and represents an attractive therapeutic target. To search for modulators of EWS/FLI1 activity we screened a library of 153 targeted compou ...[more]