Ontology highlight
ABSTRACT:
SUBMITTER: Naito A
PROVIDER: S-EPMC4358269 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Naito Atsushi A Yamamoto Hirofumi H Kagawa Yoshinori Y Naito Yoko Y Okuzaki Daisuke D Otani Keisuke K Iwamoto Yoriko Y Maeda Sakae S Kikuta Junichi J Nishikawa Keizo K Uemura Mamoru M Nishimura Junichi J Hata Taishi T Takemasa Ichiro I Mizushima Tsunekazu T Ishii Hideshi H Doki Yuichiro Y Mori Masaki M Ishii Masaru M
The Journal of biological chemistry 20150120 10
Cell cycle-arrested cancer cells are resistant to conventional chemotherapy that acts on the mitotic phases of the cell cycle, although the molecular mechanisms involved in halting cell cycle progression remain unclear. Here, we demonstrated that RFPL4A, an uncharacterized ubiquitin ligase, induced G1 retention and thus conferred decreased sensitivity to chemotherapy in the human colorectal cancer cell line, HCT116. Long term time lapse observations in HCT116 cells bearing a "fluorescence ubiqui ...[more]