Ontology highlight
ABSTRACT:
SUBMITTER: Yao Q
PROVIDER: S-EPMC4358343 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Yao Qing Q Lu Qiuhe Q Wan Xiaobo X Song Feng F Xu Yue Y Hu Mo M Zamyatina Alla A Liu Xiaoyun X Huang Niu N Zhu Ping P Shao Feng F
eLife 20141013
A large group of bacterial virulence autotransporters including AIDA-I from diffusely adhering E. coli (DAEC) and TibA from enterotoxigenic E. coli (ETEC) require hyperglycosylation for functioning. Here we demonstrate that TibC from ETEC harbors a heptosyltransferase activity on TibA and AIDA-I, defining a large family of bacterial autotransporter heptosyltransferases (BAHTs). The crystal structure of TibC reveals a characteristic ring-shape dodecamer. The protomer features an N-terminal β-barr ...[more]