Ontology highlight
ABSTRACT:
SUBMITTER: Murn J
PROVIDER: S-EPMC4358403 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Genes & development 20150301 5
Cellular morphology is an essential determinant of cellular function in all kingdoms of life, yet little is known about how cell shape is controlled. Here we describe a molecular program that controls the early morphology of neurons through a metazoan-specific zinc finger protein, Unkempt. Depletion of Unkempt in mouse embryos disrupts the shape of migrating neurons, while ectopic expression confers neuronal-like morphology to cells of different nonneuronal lineages. We found that Unkempt is a s ...[more]