Ontology highlight
ABSTRACT:
SUBMITTER: Murn J
PROVIDER: S-EPMC4703518 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Murn Jernej J Teplova Marianna M Zarnack Kathi K Shi Yang Y Patel Dinshaw J DJ
Nature structural & molecular biology 20151207 1
Unkempt is an evolutionarily conserved RNA-binding protein that regulates translation of its target genes and is required for the establishment of the early bipolar neuronal morphology. Here we determined the X-ray crystal structure of mouse Unkempt and show that its six CCCH zinc fingers (ZnFs) form two compact clusters, ZnF1-3 and ZnF4-6, that recognize distinct trinucleotide RNA substrates. Both ZnF clusters adopt a similar overall topology and use distinct recognition principles to target sp ...[more]