Ontology highlight
ABSTRACT:
SUBMITTER: Feng J
PROVIDER: S-EPMC4358444 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Feng Jianhua J Wang Qiang Q Li Guangwei G Zeng Xiangjian X Kuang Shihang S Li Xiaohua X Yue Youwei Y
International journal of clinical and experimental medicine 20150115 1
The recent studies demonstrated that the global 5-hydroxymethylcytosine (5 hmC) level decreased in prostate cancer (PCa) involved the 5-methylcytosine (5 mC) hydroxymethylase, Ten-eleven translocation (TET)1 reduction. 5 hmC and TET1 were both revealed a dual function in bivalent domain associated with developmental regulators in embryonic stem cell model. However, the mechanism underlying the DNA methylation and hydroxymethylation change mediated by TET1 downregulation in PCa remains unclear. H ...[more]