Ontology highlight
ABSTRACT:
SUBMITTER: Goodwin JF
PROVIDER: S-EPMC4531387 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Cancer cell 20150701 1
Emerging evidence demonstrates that the DNA repair kinase DNA-PKcs exerts divergent roles in transcriptional regulation of unsolved consequence. Here, in vitro and in vivo interrogation demonstrate that DNA-PKcs functions as a selective modulator of transcriptional networks that induce cell migration, invasion, and metastasis. Accordingly, suppression of DNA-PKcs inhibits tumor metastases. Clinical assessment revealed that DNA-PKcs is significantly elevated in advanced disease and independently ...[more]