Dataset Information

Role of ?-isomerized C-terminal telopeptides (?-CTx) and total procollagen type 1 amino-terminal propeptide (tP1NP) as osteosarcoma biomarkers.

ABSTRACT:

Introduction

Few serum markers are valid and useful for the diagnosis or therapeutic effect monitoring of osteosarcoma. This study aimed to investigate the role of ?-isomerized C-terminal telopeptides (?-CTx) and total procollagen type 1 amino-terminal propeptide (tP1NP) as serological biomarkers for osteosarcoma patients.

Materials and methods

A total of 48 patients with osteosarcoma and 55 healthy volunteers were investigated. Serum ?-CTx and tP1NP levels were measured by electrochemiluminescence immunoassay. Data were analyzed by t test with Walth's correction and receiver operating characteristic (ROC) curve analysis.

Results

The baseline levels of ?-CTx and tP1NP were found to be significantly higher in patients with osteosarcoma than the healthy volunteers. The mean areas under the ROC curves were 0.919 (range, 0.864-0.973) for ?-CTx and 0.866 (range, 0.792-0.939) for tP1NP. The levels of ?-CTx and tP1NP were lower in patients with stable disease after operation than those before operation.

Conclusion

These findings support our hypothesis that ?-CTx and tP1NP are promising serum biomarkers for diagnosing or monitoring osteosarcoma.

SUBMITTER: Hu T

PROVIDER: S-EPMC4358526 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Publications

Role of β-isomerized C-terminal telopeptides (β-CTx) and total procollagen type 1 amino-terminal propeptide (tP1NP) as osteosarcoma biomarkers.

Hu Tu T Yang Qingcheng Q Xu Jing J Zhang Zhichang Z He Nengbin N Du Yuzhen Y

International journal of clinical and experimental medicine 20150115 1

<h4>Introduction</h4>Few serum markers are valid and useful for the diagnosis or therapeutic effect monitoring of osteosarcoma. This study aimed to investigate the role of β-isomerized C-terminal telopeptides (β-CTx) and total procollagen type 1 amino-terminal propeptide (tP1NP) as serological biomarkers for osteosarcoma patients.<h4>Materials and methods</h4>A total of 48 patients with osteosarcoma and 55 healthy volunteers were investigated. Serum β-CTx and tP1NP levels were measured by electr ...[more]

PMID: 25785071

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