Ontology highlight
ABSTRACT:
SUBMITTER: Yang X
PROVIDER: S-EPMC4359088 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Yang Xinglong X Liu Chuanxin C Zhang Jinxiang J Han Hongying H Wang Xiuyan X Liu Zhoulin Z Xu Yanming Y
PloS one 20150313 3
Parkinson's disease (PD) and schizophrenia (SCZ) are frequent central nervous disorders that have unclear etiologies but that show similarities in their pathogenesis. Since elevated histamine levels in the brain have been associated with PD and SCZ, we wanted to explore whether the Thr105Ile substitution in the histamine N-methyltransferase gene (HNMT-Thr105Ile), which impairs histamine degradation, is associated with either disease. We used the ligase detection reaction to genotype a case-contr ...[more]