Dataset Information

Association of ARNTL and PER1 genes with Parkinson's disease: a case-control study of Han Chinese.

ABSTRACT: Circadian disruptions may result in sleep problems, oxidative stress and an altered inflammatory response. These symptoms may contribute to PD pathogenesis, despite a lack of direct experimental evidence supporting this relationship. Clock genes are essential to drive and maintain circadian rhythm. To elucidate the possible role of circadian disruptions in PD, we investigated 132 tag variants in eight clock genes. We genotyped these tags within 1,394 Chinese cases and 1,342 controls using Illumina GoldenGate chips. We discovered that SNPs in ARNTL (rs900147, P = 3.33 × 10(-5), OR = 0.80) and PER1 (rs2253820, P = 5.30 × 10(-6), OR = 1.31) genes are significantly associated with PD risk. Moreover, the positive association of the ARNTL rs900147 variant was more robust in tremor dominant (TD) (P = 3.44 × 10(-4)) than postural instability and gait difficulty (PIGD) cases (P = 6.06 × 10(-2)). The association of the PER1 rs2253820 variant was more robust in PIGD (P = 5.42 × 10(-5)) than TD cases (P = 4.2 × 10(-2)). Haplotype analysis also showed that ARNTL and PER1 were associated with PD. Imputation analysis identified more SNPs within ARNTL and PER1 associated with PD, some of which may affect gene expression through altering the transcription factor binding site. In summary, our findings suggest that genetic polymorphisms in ARNTL and PER1 genes, as well as circadian disruptions, may contribute to PD pathogenesis.

SUBMITTER: Gu Z

PROVIDER: S-EPMC4623766 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Association of ARNTL and PER1 genes with Parkinson's disease: a case-control study of Han Chinese.

Gu Zhuqin Z Wang BinBin B Zhang Yong-Biao YB Ding Hui H Zhang Yanli Y Yu Jun J Gu Mingliang M Chan Piu P Cai Yanning Y

Scientific reports 20151028

Circadian disruptions may result in sleep problems, oxidative stress and an altered inflammatory response. These symptoms may contribute to PD pathogenesis, despite a lack of direct experimental evidence supporting this relationship. Clock genes are essential to drive and maintain circadian rhythm. To elucidate the possible role of circadian disruptions in PD, we investigated 132 tag variants in eight clock genes. We genotyped these tags within 1,394 Chinese cases and 1,342 controls using Illumi ...[more]

PMID: 26507264

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Project description:Evidence has shown that the CUB and Sushi Multiple Domains (CSMD1) gene is an inhibitor of the complement activation pathway and is also involved in central nervous system inflammation. Previous studies have revealed that the CSMD1 gene is related to familial Parkinson's disease. This study aimed to investigate the relationship between CSMD1 gene and susceptibility to Parkinson's disease in population of northern China. A case-control study was performed on 423 Parkinson's disease patients and 465 healthy controls matched for age and sex. DNA from enrolled subjects were extracted from the peripheral blood, and single nucleotide polymorphisms (SNPs) rs12681349 (C?T), rs10503253 (C?A), and rs1983474 (T?G) within CSMD1 gene were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Genotype frequency of rs10503253 (CA versus CC?:?OR?=?1.554, 95% CI?=?1.169-2.066, p=0.002) and rs1983474 (GG versus TT?:?OR?=?0.599, 95% CI?=?0.401-0.895, p=0.012) was significantly different between PD cases and controls, but not for rs12681349. Comprehensive and subgroup analysis indicated that rs10503252 showed significant statistical differences in the dominant model (AA?+?CA versus CC?:?OR?=?0.677, 95% CI?=?0.517-0.886, p=0.004), late-onset cohort (CA versus CC?:?OR?=?1.570, 95% CI?=?1.159-2.126, p=0.004), and the female cohort (CA versus CC?:?OR?=?0.687, 95% CI?=?0.497-0.952, p=0.023), compared with the matched control group. The difference of recessive model of rs1983474 (GG versus TT?+?TG?:?OR?=?1.837, 95% CI?=?1.287-2.620, p=0.001) was significant in Parkinson's disease. According to the subgroup analysis, results indicated that late-onset cohort (GG versus TT?:?OR?=?0.643, 95% CI?=?0.420-0.985, p=0.042), male cohort (TG versus TT?:?OR?=?2.160, 95% CI?=?1.162-4.016, p=0.015), and female group (GG versus TT?:?OR?=?0.418, 95% CI?=?0.234-0.746, p=0.003) of rs1983474 were significantly associated with Parkinson's disease susceptibility. In both genotype and subgroup analysis, we failed to find any relationship between rs12681349 polymorphism and Parkinson's disease risk. Our results indicate that the rs10503253 and rs1983474 gene polymorphism may be associated with idiopathic Parkinson's disease susceptibility in Chinese population. Nevertheless, these conclusions need to be further verified by more studies.

Dataset Information

Association of ARNTL and PER1 genes with Parkinson's disease: a case-control study of Han Chinese.

Publications

Association of ARNTL and PER1 genes with Parkinson's disease: a case-control study of Han Chinese.

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