Ontology highlight
ABSTRACT:
SUBMITTER: Yousfi N
PROVIDER: S-EPMC4359111 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Yousfi Nadhir N Pruvot Benoist B Lopez Tatiana T Magadoux Lea L Franche Nathalie N Pichon Laurent L Salvadori Françoise F Solary Eric E Garrido Carmen C Laurens Véronique V Chluba Johanna J
PloS one 20150313 3
To investigate the effect of nitric oxide on tumor development, we established a rat tumor xenograft model in zebrafish embryos. The injected tumor cells formed masses in which nitric oxide production could be detected by the use of the cell-permeant DAF-FM-DA (diaminofluorophore 4-amino-5-methylamino-2'-7'-difluorofluorescein diacetate) and DAR-4M-AM (diaminorhodamine-4M). This method revealed that nitric oxide production could be co-localized with the tumor xenograft in 46% of the embryos. In ...[more]