Ontology highlight
ABSTRACT:
SUBMITTER: Fogal V
PROVIDER: S-EPMC4359224 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Fogal Valentina V Babic Ivan I Chao Ying Y Pastorino Sandra S Mukthavaram Rajesh R Jiang Pengfei P Cho Yoon-Jae YJ Pingle Sandeep C SC Crawford John R JR Piccioni David E DE Kesari Santosh S
Oncotarget 20150101 2
Metabolic reprogramming is a key feature of tumorigenesis that is controlled by oncogenes. Enhanced utilization of glucose and glutamine are the best-established hallmarks of tumor metabolism. The oncogene c-Myc is one of the major players responsible for this metabolic alteration. However, the molecular mechanisms involved in Myc-induced metabolic reprogramming are not well defined. Here we identify p32, a mitochondrial protein known to play a role in the expression of mitochondrial respiratory ...[more]