Ontology highlight
ABSTRACT:
SUBMITTER: Darcy DG
PROVIDER: S-EPMC4359253 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Darcy David G DG Chiaroni-Clarke Rachel R Murphy Jennifer M JM Honeyman Joshua N JN Bhanot Umesh U LaQuaglia Michael P MP Simon Sanford M SM
Oncotarget 20150101 2
Fibrolamellar hepatocellular carcinoma is a rare, malignant liver tumor that often arises in the otherwise normal liver of adolescents and young adults. Previous studies have focused on biomarkers and comparisons to traditional hepatocellular carcinoma, and have yielded little data on the underlying pathophysiology. We performed whole genome sequencing on paired tumor and normal samples from 10 patients to identify recurrent mutations and structural variations that could predispose to oncogenesi ...[more]