Ontology highlight
ABSTRACT:
SUBMITTER: Giorgi C
PROVIDER: S-EPMC4359305 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Giorgi Carlotta C Bonora Massimo M Missiroli Sonia S Poletti Federica F Ramirez Fabian Galindo FG Morciano Giampaolo G Morganti Claudia C Pandolfi Pier Paolo PP Mammano Fabio F Pinton Paolo P
Oncotarget 20150101 3
One challenge in biology is signal transduction monitoring in a physiological context. Intravital imaging techniques are revolutionizing our understanding of tumor and host cell behaviors in the tumor environment. However, these deep tissue imaging techniques have not yet been adopted to investigate the second messenger calcium (Ca²⁺). In the present study, we established conditions that allow the in vivo detection of Ca²⁺ signaling in three-dimensional tumor masses in mouse models. By combining ...[more]