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Plant antimicrobial peptides as potential anticancer agents.

ABSTRACT: Antimicrobial peptides (AMPs) are part of the innate immune defense mechanism of many organisms and are promising candidates to treat infections caused by pathogenic bacteria to animals and humans. AMPs also display anticancer activities because of their ability to inactivate a wide range of cancer cells. Cancer remains a cause of high morbidity and mortality worldwide. Therefore, the development of methods for its control is desirable. Attractive alternatives include plant AMP thionins, defensins, and cyclotides, which have anticancer activities. Here, we provide an overview of plant AMPs anticancer activities, with an emphasis on their mode of action, their selectivity, and their efficacy.

SUBMITTER: Guzman-Rodriguez JJ

PROVIDER: S-EPMC4359852 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Plant antimicrobial peptides as potential anticancer agents.

Guzmán-Rodríguez Jaquelina Julia JJ Ochoa-Zarzosa Alejandra A López-Gómez Rodolfo R López-Meza Joel E JE

BioMed research international 20150301

Antimicrobial peptides (AMPs) are part of the innate immune defense mechanism of many organisms and are promising candidates to treat infections caused by pathogenic bacteria to animals and humans. AMPs also display anticancer activities because of their ability to inactivate a wide range of cancer cells. Cancer remains a cause of high morbidity and mortality worldwide. Therefore, the development of methods for its control is desirable. Attractive alternatives include plant AMP thionins, defensi ...[more]

PMID: 25815333

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