Ontology highlight
ABSTRACT:
SUBMITTER: Schwartz-Roberts JL
PROVIDER: S-EPMC4359953 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Schwartz-Roberts Jessica L JL Cook Katherine L KL Chen Chun C Shajahan-Haq Ayesha N AN Axelrod Margaret M Wärri Anni A Riggins Rebecca B RB Jin Lu L Haddad Bassem R BR Kallakury Bhaskar V BV Baumann William T WT Clarke Robert R
Cancer research 20150109 6
Interferon regulatory factor-1 (IRF1) is a tumor suppressor that regulates cell fate in several cell types. Here, we report an inverse correlation in expression of nuclear IRF1 and the autophagy regulator ATG7 in human breast cancer cells that directly affects their cell fate. In mice harboring mutant Atg7, nuclear IRF1 was increased in mammary tumors, spleen, and kidney. Mechanistic investigations identified ATG7 and the cell death modulator beclin-1 (BECN1) as negative regulators of IRF1. Sile ...[more]