Ontology highlight
ABSTRACT:
SUBMITTER: Nepomuceno GM
PROVIDER: S-EPMC4360151 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Nepomuceno Gabriella M GM Chan Katie M KM Huynh Valerie V Martin Kevin S KS Moore Jared T JT O'Brien Terrence E TE Pollo Luiz A E LA Sarabia Francisco J FJ Tadeus Clarissa C Yao Zi Z Anderson David E DE Ames James B JB Shaw Jared T JT
ACS medicinal chemistry letters 20150107 3
The bacterial cell division protein FtsZ is one of many potential targets for the development of novel antibiotics. Recently, zantrin Z3 was shown to be a cross-species inhibitor of FtsZ; however, its specific interactions with the protein are still unknown. Herein we report the synthesis of analogues that contain a more tractable core structure and an analogue with single-digit micromolar inhibition of FtsZ's GTPase activity, which represents the most potent inhibitor of Escherichia coli FtsZ r ...[more]