Ontology highlight
ABSTRACT:
SUBMITTER: Tatani K
PROVIDER: S-EPMC4360153 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20150128 3
Purine-rich foods have long been suspected as a major cause of hyperuricemia. We hypothesized that inhibition of human concentrative nucleoside transporter 2 (hCNT2) would suppress increases in serum urate levels derived from dietary purines. To test this hypothesis, the development of potent hCNT2 inhibitors was required. By modifying adenosine, an hCNT2 substrate, we successfully identified 8-aminoadenosine derivatives as a new class of hCNT2 inhibitors. Compound 12 moderately inhibited hCNT2 ...[more]