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Synthesis of New DPP-4 Inhibitors Based on a Novel Tricyclic Scaffold.

ABSTRACT: A novel molecular scaffold has been synthesized, and its synthesis and incorporation into new analogues of biologically active molecules will be discussed. A comparison of the inhibitory activity of these compounds to the known type-2 diabetes compound (sitagliptin) against dipeptidyl peptidase-4 (DPP-4) will be shown.

SUBMITTER: Schwehm C

PROVIDER: S-EPMC4360159 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Synthesis of New DPP-4 Inhibitors Based on a Novel Tricyclic Scaffold.

Schwehm Carolin C Li Jin J Song Hongmei H Hu Xiao X Kellam Barrie B Stocks Michael J MJ

ACS medicinal chemistry letters 20150113 3

A novel molecular scaffold has been synthesized, and its synthesis and incorporation into new analogues of biologically active molecules will be discussed. A comparison of the inhibitory activity of these compounds to the known type-2 diabetes compound (sitagliptin) against dipeptidyl peptidase-4 (DPP-4) will be shown. ...[more]

PMID: 25815154

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