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Synthesis, biological activity and molecular docking of new tricyclic series as ?-glucosidase inhibitors.

ABSTRACT: Diabetes is an emerging metabolic disorder. ?-Glucosidase inhibitors, such as acarbose, delay the hydrolysis of carbohydrates by interfering with the digestive enzymes. This action decreases the glucose absorption and the postprandial glucose level. We have synthesized 25 tricyclic 2-phenoxypyrido[3,2-e][1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones hybrids and evaluated their ?-glucosidase inhibitory activity. Compounds 6h and 6d have shown stronger activity than that of acarbose. Compound 6h exhibited the highest inhibition with an IC50 of 104.07 µM. Molecular modelling studies revealed that compound 6h inhibits ?-glucosidase due to the formation of a stable ligand-?-glucosidase complex and extra hydrogen bond interactions, and directed in the binding site by Trp329.25 tricyclic 2-phenoxypyrido[3,2-e][1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones hybrids have been synthesized and evaluated their ?-glucosidase inhibitory activity. Compounds 6h have shown stronger activity than that of acarbose.

SUBMITTER: Abuelizz HA 

PROVIDER: S-EPMC6661812 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Synthesis, biological activity and molecular docking of new tricyclic series as α-glucosidase inhibitors.

Abuelizz Hatem A HA   Iwana Nor Azman N I NANI   Ahmad Rohaya R   Anouar El-Hassane EH   Marzouk Mohamed M   Al-Salahi Rashad R  

BMC chemistry 20190405 1

Diabetes is an emerging metabolic disorder. α-Glucosidase inhibitors, such as acarbose, delay the hydrolysis of carbohydrates by interfering with the digestive enzymes. This action decreases the glucose absorption and the postprandial glucose level. We have synthesized 25 tricyclic 2-phenoxypyrido[3,2-<i>e</i>][1,2,4]triazolo[1,5-<i>a</i>]pyrimidin-5(4H)-ones hybrids and evaluated their α-glucosidase inhibitory activity. Compounds <b>6h</b> and <b>6d</b> have shown stronger activity than that of  ...[more]

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