Ontology highlight
ABSTRACT:
SUBMITTER: Abuelizz HA
PROVIDER: S-EPMC6661812 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Abuelizz Hatem A HA Iwana Nor Azman N I NANI Ahmad Rohaya R Anouar El-Hassane EH Marzouk Mohamed M Al-Salahi Rashad R
BMC chemistry 20190405 1
Diabetes is an emerging metabolic disorder. α-Glucosidase inhibitors, such as acarbose, delay the hydrolysis of carbohydrates by interfering with the digestive enzymes. This action decreases the glucose absorption and the postprandial glucose level. We have synthesized 25 tricyclic 2-phenoxypyrido[3,2-<i>e</i>][1,2,4]triazolo[1,5-<i>a</i>]pyrimidin-5(4H)-ones hybrids and evaluated their α-glucosidase inhibitory activity. Compounds <b>6h</b> and <b>6d</b> have shown stronger activity than that of ...[more]