Ontology highlight
ABSTRACT:
SUBMITTER: Codega P
PROVIDER: S-EPMC4360885 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Neuron 20140501 3
Adult neurogenic niches harbor quiescent neural stem cells; however, their in vivo identity has been elusive. Here, we prospectively isolate GFAP(+)CD133(+) (quiescent neural stem cells [qNSCs]) and GFAP(+)CD133(+)EGFR(+) (activated neural stem cells [aNSCs]) from the adult ventricular-subventricular zone. aNSCs are rapidly cycling, highly neurogenic in vivo, and enriched in colony-forming cells in vitro. In contrast, qNSCs are largely dormant in vivo, generate olfactory bulb interneurons with s ...[more]