Ontology highlight
ABSTRACT:
SUBMITTER: Herrlinger EM
PROVIDER: S-EPMC7497180 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Herrlinger Eva-Maria EM Hau Mirjam M Redhaber Desiree Melanie DM Greve Gabriele G Willmann Dominica D Steimle Simon S Müller Michael M Lübbert Michael M Miething Christoph Cornelius CC Schüle Roland R Jung Manfred M
Chembiochem : a European journal of chemical biology 20200427 16
Lysine-specific demethylase 1 (LSD1) has evolved as a promising therapeutic target for cancer treatment, especially in acute myeloid leukaemia (AML). To approach the challenge of site-specific LSD1 inhibition, we developed an enzyme-prodrug system with the bacterial nitroreductase NfsB (NTR) that was expressed in the virally transfected AML cell line THP1-NTR<sup>+</sup> . The cellular activity of the NTR was proven with a new luminescent NTR probe. We synthesised a diverse set of nitroaromatic ...[more]