Ontology highlight
ABSTRACT:
SUBMITTER: Murugaiyan G
PROVIDER: S-EPMC4362225 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Murugaiyan Gopal G da Cunha Andre Pires AP Ajay Amrendra K AK Joller Nicole N Garo Lucien P LP Kumaradevan Sowmiya S Yosef Nir N Vaidya Vishal S VS Weiner Howard L HL
The Journal of clinical investigation 20150202 3
Accumulation of IL-17-producing Th17 cells is associated with the development of multiple autoimmune diseases; however, the contribution of microRNA (miRNA) pathways to the intrinsic control of Th17 development remains unclear. Here, we demonstrated that miR-21 expression is elevated in Th17 cells and that mice lacking miR-21 have a defect in Th17 differentiation and are resistant to experimental autoimmune encephalomyelitis (EAE). Furthermore, we determined that miR-21 promotes Th17 differentia ...[more]