Ontology highlight
ABSTRACT:
SUBMITTER: Pena K
PROVIDER: S-EPMC4363267 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Peña Karina K Coblenz Jessica J Kiselyov Kirill K
Cell calcium 20150112 4
Copper (Cu) is essential mineral, but its toxicity necessitates existence of powerful machinery responsible for the extraction of excess Cu from the cell. Cu exposure was recently shown to induce the translocation of Cu pump ATP7B to the lysosomes followed by lysosomal exocytosis. Here we sought to investigate the mechanisms underlying the effect of Cu on lysosomal exocytosis. We found that brief exposure to Cu activates lysosomal exocytosis, which was measured as a release of the lysosomal dige ...[more]