Ontology highlight
ABSTRACT:
SUBMITTER: Choi YJ
PROVIDER: S-EPMC4363657 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Choi Yun Jung YJ Kim Seon Ye SY So Kwang Sup KS Baek In-Jeoung IJ Kim Woo Sung WS Choi Se Hoon SH Lee Jae Cheol JC Bivona Trever G TG Rho Jin Kyung JK Choi Chang-Min CM
PloS one 20150317 3
The activation of bypass signals, such as MET and AXL, has been identified as a possible mechanism of EGFR-TKI resistance. Because various oncoproteins depend on HSP90 for maturation and stability, we investigated the effects of AUY922, a newly developed non-geldanamycin class HSP90 inhibitor, in lung cancer cells with MET- and AXL-mediated resistance. We established resistant cell lines with HCC827 cells harboring an exon 19-deletion mutation in of the EGFR gene via long-term exposure to increa ...[more]