Ontology highlight
ABSTRACT:
SUBMITTER: Ozden O
PROVIDER: S-EPMC4364304 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Free radical biology & medicine 20140822
Pyruvate dehydrogenase E1α (PDHA1) is the first component enzyme of the pyruvate dehydrogenase (PDH) complex that transforms pyruvate, via pyruvate decarboxylation, into acetyl-CoA that is subsequently used by both the citric acid cycle and oxidative phosphorylation to generate ATP. As such, PDH links glycolysis and oxidative phosphorylation in normal as well as cancer cells. Herein we report that SIRT3 interacts with PDHA1 and directs its enzymatic activity via changes in protein acetylation. S ...[more]