Interleukin-18 has antipermeablity and antiangiogenic activities in the eye: reciprocal suppression with VEGF.
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ABSTRACT:
SUBMITTER: Shen J
PROVIDER: S-EPMC4364659 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
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Interleukin-18 has antipermeablity and antiangiogenic activities in the eye: reciprocal suppression with VEGF.
Shen Jikui J Choy David F DF Yoshida Tsunehiko T Iwase Takeshi T Hafiz Gulnar G Xie Bing B Hackett Sean F SF Arron Joseph R JR Campochiaro Peter A PA
Journal of cellular physiology 20140801 8
Interleukin-18 (IL-18) is increased along with IL-1β by activation of the inflammasome and has been implicated in inflammatory and autoimmune diseases, but its role in the eye is uncertain. In patients with macular edema due to retinal vein occlusion, intraocular IL-18 levels increased significantly (P < 0.001) after treatment with ranibizumab particularly in patients with high baseline IL-18 which correlated with good visual outcome (P < 0.05). In mice with ischemic retinopathy, suppression of ...[more]
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