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Cabut/dTIEG associates with the transcription factor Yorkie for growth control.

ABSTRACT: The Drosophila transcription factor Cabut/dTIEG (Cbt) is a growth regulator, whose expression is modulated by different stimuli. Here, we determine Cbt association with chromatin and identify Yorkie (Yki), the transcriptional co-activator of the Hippo (Hpo) pathway as its partner. Cbt and Yki co-localize on common gene promoters, and the expression of target genes varies according to changes in Cbt levels. Down-regulation of Cbt suppresses the overgrowth phenotypes caused by mutations in expanded (ex) and yki overexpression, whereas its up-regulation promotes cell proliferation. Our results imply that Cbt is a novel partner of Yki that is required as a transcriptional co-activator in growth control.

SUBMITTER: Ruiz-Romero M

PROVIDER: S-EPMC4364875 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Cabut/dTIEG associates with the transcription factor Yorkie for growth control.

Ruiz-Romero Marina M Blanco Enrique E Paricio Nuria N Serras Florenci F Corominas Montserrat M

EMBO reports 20150108 3

The Drosophila transcription factor Cabut/dTIEG (Cbt) is a growth regulator, whose expression is modulated by different stimuli. Here, we determine Cbt association with chromatin and identify Yorkie (Yki), the transcriptional co-activator of the Hippo (Hpo) pathway as its partner. Cbt and Yki co-localize on common gene promoters, and the expression of target genes varies according to changes in Cbt levels. Down-regulation of Cbt suppresses the overgrowth phenotypes caused by mutations in expande ...[more]

PMID: 25572844

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