Ontology highlight
ABSTRACT:
SUBMITTER: Ford ML
PROVIDER: S-EPMC4365450 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Ford Mandy L ML Adams Andrew B AB Pearson Thomas C TC
Nature reviews. Nephrology 20131008 1
The myriad of co-stimulatory signals expressed, or induced, upon T-cell activation suggests that these signalling pathways shape the character and magnitude of the resulting autoreactive or alloreactive T-cell responses during autoimmunity or transplantation, respectively. Reducing pathological T-cell responses by targeting T-cell co-stimulatory pathways has met with therapeutic success in many instances, but challenges remain. In this Review, we discuss the T-cell co-stimulatory molecules that ...[more]