Immunotherapies targeting stimulatory pathways and beyond.
Ontology highlight
ABSTRACT:
SUBMITTER: Marin-Acevedo JA
PROVIDER: S-EPMC8117548 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Publications
Immunotherapies targeting stimulatory pathways and beyond.
Marin-Acevedo Julian A JA Kimbrough ErinMarie O EO Manochakian Rami R Zhao Yujie Y Lou Yanyan Y
Journal of hematology & oncology 20210512 1
Co-stimulatory and co-inhibitory molecules play a critical role in T cell function. Tumor cells escape immune surveillance by promoting immunosuppression. Immunotherapy targeting inhibitory molecules like anti-CTLA-4 and anti-PD-1/PD-L1 were developed to overcome these immunosuppressive effects. These agents have demonstrated remarkable, durable responses in a small subset of patients. The other mechanisms for enhancing anti-tumor activities are to target the stimulatory pathways that are expres ...[more]
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