Mutations of mitochondrial genome in carotid atherosclerosis.
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ABSTRACT:
SUBMITTER: Sazonova MA
PROVIDER: S-EPMC4365735 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Mutations of mitochondrial genome in carotid atherosclerosis.
Sazonova Margarita A MA Zhelankin Andrey V AV Barinova Valeria A VA Sinyov Vasily V VV Khasanova Zukhra B ZB Postnov Anton Y AY Orekhov Alexander N AN Bobryshev Yuri V YV Sobenin Igor A IA
Frontiers in genetics 20150319
With aim of detection the spectrum of mitochondrial DNA mutations in patients with carotid atherosclerosis from Moscow Region, we used a Roche 454 high-throughput sequencing of the whole mitochondrial genome. We have found that the presence of a number of homoplasmic mitochondrial DNA mutations in genes of 16S ribosomal RNA, subunits 2, 4, and 5 NADH dehydrogenase, subunits 1 and 2 cytochrome C oxidase, subunit 6 ATP-synthase, tRNA- Leu 2 and cytochrome B differed between conventionally healthy ...[more]
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