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The APOB insertion/deletion polymorphism (rs17240441) influences postprandial lipaemia in healthy adults.


ABSTRACT: BACKGROUND:Apolipoprotein (apo)B is the structural apoprotein of intestinally- and liver- derived lipoproteins and plays an important role in the transport of triacylglycerol (TAG) and cholesterol. Previous studies have examined the association between the APOB insertion/deletion (ins/del) polymorphism (rs17240441) and postprandial lipaemia in response to a single meal; however the findings have been inconsistent with studies often underpowered to detect genotype-lipaemia associations, focused mainly on men, or with limited postprandial characterisation of participants. In the present study, using a novel sequential test meal protocol which more closely mimics habitual eating patterns, we investigated the impact of APOB ins/del polymorphism on postprandial TAG, non-esterified fatty acids, glucose and insulin levels in healthy adults. FINDINGS:Healthy participants (n?=?147) consumed a standard test breakfast (0 min; 49 g fat) and lunch (330 min; 29 g fat), with blood samples collected before (fasting) and on 11 subsequent occasions until 480 min after the test breakfast. The ins/ins homozygotes had higher fasting total cholesterol, LDL-cholesterol, TAG, insulin and HOMA-IR and lower HDL-cholesterol than del/del homozygotes (P?

SUBMITTER: Vimaleswaran KS 

PROVIDER: S-EPMC4365815 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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The APOB insertion/deletion polymorphism (rs17240441) influences postprandial lipaemia in healthy adults.

Vimaleswaran Karani Santhanakrishnan KS   Minihane Anne M AM   Li Yue Y   Gill Rosalyn R   Lovegrove Julie A JA   Williams Christine M CM   Jackson Kim G KG  

Nutrition & metabolism 20150308


<h4>Background</h4>Apolipoprotein (apo)B is the structural apoprotein of intestinally- and liver- derived lipoproteins and plays an important role in the transport of triacylglycerol (TAG) and cholesterol. Previous studies have examined the association between the APOB insertion/deletion (ins/del) polymorphism (rs17240441) and postprandial lipaemia in response to a single meal; however the findings have been inconsistent with studies often underpowered to detect genotype-lipaemia associations, f  ...[more]

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