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Carbapenemase-producing Klebsiella pneumoniae: molecular and genetic decoding.

ABSTRACT: Klebsiella pneumoniae carbapenemases (KPCs) were first identified in 1996 in the USA. Since then, regional outbreaks of KPC-producing K. pneumoniae (KPC-Kp) have occurred in the USA, and have spread internationally. Dissemination of blaKPC involves both horizontal transfer of blaKPC genes and plasmids, and clonal spread. Of epidemiological significance, the international spread of KPC-producing K. pneumoniae is primarily associated with a single multilocus sequence type (ST), ST258, and its related variants. However, the molecular factors contributing to the success of ST258 largely remain unclear. In this review, we discuss the recent progresses in understanding KPC-producing K. pneumoniae that are contributing to our knowledge of plasmid and genome composition and structure among the KPC epidemic clone, and we identify possible factors that influence its epidemiological success.

SUBMITTER: Chen L

PROVIDER: S-EPMC4365952 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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Carbapenemase-producing Klebsiella pneumoniae: molecular and genetic decoding.

Chen Liang L Mathema Barun B Chavda Kalyan D KD DeLeo Frank R FR Bonomo Robert A RA Kreiswirth Barry N BN

Trends in microbiology 20141007 12

Klebsiella pneumoniae carbapenemases (KPCs) were first identified in 1996 in the USA. Since then, regional outbreaks of KPC-producing K. pneumoniae (KPC-Kp) have occurred in the USA, and have spread internationally. Dissemination of blaKPC involves both horizontal transfer of blaKPC genes and plasmids, and clonal spread. Of epidemiological significance, the international spread of KPC-producing K. pneumoniae is primarily associated with a single multilocus sequence type (ST), ST258, and its rela ...[more]

PMID: 25304194

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