Ontology highlight
ABSTRACT:
SUBMITTER: He J
PROVIDER: S-EPMC4366635 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
He Jin J Li Qiuyan Q Fang Suyun S Guo Ying Y Liu Tongxin T Ye Jianhua J Yu Zhengquan Z Zhang Ran R Zhao Yaofeng Y Hu Xiaoxiang X Bai Xueyuan X Chen Xiangmei X Li Ning N
International journal of biological sciences 20150210 4
PKD1 and PKD2 mutations could lead to autosomal dominant polycystic kidney disease (ADPKD), which afflicts millions of people worldwide. Due to the marked differences in the lifespan, size, anatomy, and physiology from humans, rodent ADPKD models cannot fully mimic the disease. To obtain a large animal model that recapitulates the disease, we constructed a mini-pig model by mono-allelic knockout (KO) of PKD1 using zinc finger nuclease. The mono-allelic KO pigs had lower PKD1 expression than thei ...[more]