Ontology highlight
ABSTRACT:
SUBMITTER: Lai Y
PROVIDER: S-EPMC4366854 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Lai Ying Y Lou Xiaochu X Diao Jiajie J Shin Yeon-Kyun YK
Scientific reports 20150320
Synaptotagmin 1 (Syt1), a major Ca(2+) sensor in neuroexocytosis, utilizes SNARE- and membrane-binding to regulate vesicle fusion, a required process for neurotransmitter release at the synapse. However, the mechanism by which Syt1 orchestrates SNARE- and membrane- binding to control individual vesicle fusion steps is still unclear. In this study, we used a number of single vesicle assays that can differentiate intermediates of neuroexocytosis, to focus on Syt1 mutants that might impair Syt1-SNA ...[more]