Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors.
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ABSTRACT:
SUBMITTER: Gao ZG
PROVIDER: S-EPMC4367543 | biostudies-literature | 2004 May
REPOSITORIES: biostudies-literature
Publications
Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors.
Gao Zhan-Guo ZG Gross Ariel S AS Jacobson Kenneth A KA
Life sciences 20040501 25
The G protein-coupled receptor allosteric modulator SCH-202676 (N-(2,3-diphenyl-1,2,4-thiadiazol-5-(2H)-ylidene)methanamine), which affects a wide range of structurally unrelated G protein-coupled receptors, has highly divergent effects on purine receptors. SCH-202676 inhibited radioligand binding to human adenosine A(1), A(2A), and A(3) receptors (IC(50) = 0.5-0.8 microM) and affected dissociation kinetics, but at the human P2Y(1) nucleotide receptor it had no effect. SCH-202676 (10 microM) sel ...[more]
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