RET-targeting molecular stratified non-small-cell lung cancers.
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ABSTRACT:
SUBMITTER: Tsuchihara K
PROVIDER: S-EPMC4367625 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Publications
RET-targeting molecular stratified non-small-cell lung cancers.
Translational lung cancer research 20131201 6
Recent advances in lung cancer genomics have successfully characterized therapeutic targets of lung cancer. RET fusion gene products are among the newest target molecules for lung adenocarcinoma. Preclinical findings and preliminary reports regarding potential tumor control by RET-targeting multi-kinase inhibitors encourage further clinical trials. The infrequent prevalence of RET fusion gene-positive cases may be a major obstacle hindering the development of RET-targeted therapy. Thus, it is ne ...[more]
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