Ontology highlight
ABSTRACT:
SUBMITTER: Rao JN
PROVIDER: S-EPMC4367809 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Rao Jampani Nageswara JN Madasu Yadaiah Y Dominguez Roberto R
Science (New York, N.Y.) 20140701 6195
Proteins that cap the ends of the actin filament are essential regulators of cytoskeleton dynamics. Whereas several proteins cap the rapidly growing barbed end, tropomodulin (Tmod) is the only protein known to cap the slowly growing pointed end. The lack of structural information severely limits our understanding of Tmod's capping mechanism. We describe crystal structures of actin complexes with the unstructured amino-terminal and the leucine-rich repeat carboxy-terminal domains of Tmod. The str ...[more]