Ontology highlight
ABSTRACT:
SUBMITTER: Kotila T
PROVIDER: S-EPMC6876575 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Kotila Tommi T Wioland Hugo H Enkavi Giray G Kogan Konstantin K Vattulainen Ilpo I Jégou Antoine A Romet-Lemonne Guillaume G Lappalainen Pekka P
Nature communications 20191122 1
The ability of cells to generate forces through actin filament turnover was an early adaptation in evolution. While much is known about how actin filaments grow, mechanisms of their disassembly are incompletely understood. The best-characterized actin disassembly factors are the cofilin family proteins, which increase cytoskeletal dynamics by severing actin filaments. However, the mechanism by which severed actin filaments are recycled back to monomeric form has remained enigmatic. We report tha ...[more]