Ontology highlight
ABSTRACT:
SUBMITTER: Bresnick AR
PROVIDER: S-EPMC4369764 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Bresnick Anne R AR Weber David J DJ Zimmer Danna B DB
Nature reviews. Cancer 20150201 2
In humans, the S100 protein family is composed of 21 members that exhibit a high degree of structural similarity, but are not functionally interchangeable. This family of proteins modulates cellular responses by functioning both as intracellular Ca(2+) sensors and as extracellular factors. Dysregulated expression of multiple members of the S100 family is a common feature of human cancers, with each type of cancer showing a unique S100 protein profile or signature. Emerging in vivo evidence indic ...[more]