Binding of transition metals to S100 proteins.
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ABSTRACT:
SUBMITTER: Gilston BA
PROVIDER: S-EPMC5123432 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
Binding of transition metals to S100 proteins.
Gilston Benjamin A BA Skaar Eric P EP Chazin Walter J WJ
Science China. Life sciences 20160719 8
The S100 proteins are a unique class of EF-hand Ca(2+) binding proteins distributed in a cell-specific, tissue-specific, and cell cycle-specific manner in humans and other vertebrates. These proteins are distinguished by their distinctive homodimeric structure, both intracellular and extracellular functions, and the ability to bind transition metals at the dimer interface. Here we summarize current knowledge of S100 protein binding of Zn(2+), Cu(2+) and Mn(2+) ions, focusing on binding affinitie ...[more]
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