Ontology highlight
ABSTRACT:
SUBMITTER: Bos M
PROVIDER: S-EPMC4369857 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Bos Marc M Gardizi Masyar M Schildhaus Hans-Ulrich HU Buettner Reinhard R Wolf Juergen J
Translational lung cancer research 20130401 2
Rearrangements of ROS1 and RET have been recently described as new driver mutations in lung adenocarcinoma with a frequency of about 1% each. RET and ROS1 rearrangements both represent unique molecular subsets of lung adenocarcinoma with virtually no overlap with other known driver mutations described so far in lung adenocarcinoma. Specific clinicopathologic characteristics have been described and several multitargeted receptor kinase inhibitors have shown in vitro activity against NSCLC cells h ...[more]